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Nursing Care of Children with Orofacial Clefts
Svobodová, Hana ; Hošťálková, Monika (advisor) ; Babická, Marcela (referee)
In the theoretical part I deal with cleft lip and palate, their distribution, risk factors, prevention, diagnosis and tretment. It also the nursing care of children with cleft lip/palate the infant and toddler period. The main objective of the thesis is to determine what is the nursing care for children with orofacial cleft. In addition, three sub-objectives have been established. The first goal was to find out what the nursing care is in the field of nutrition in children with cleft face. The second goal was to survey, what the nursing care of is wound in children after orofacial surgery. The last goal was to learn about the parents' awareness of the care with facial cleft. All objectives have been met. For the qualitative research as a method for data collection, was used nursing care report. The default method for the assembly of two case reports, was conducted and interview with mothers of children according to the structure of the model by M. Gordon - Model functional health patterns. Furthermore, the method of observation was used to compile the said case reports, and so was used medical documentation. Key words: orofacial cleft, children, nursing care, prevention, congenital anomalies
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Molecular basic of disorders of sexual development in human
Kopanicová, Eliška ; Šípek, Antonín (advisor) ; Liška, František (referee)
The development of human internal and external reprodictive organs is regulated on chromosomal, gene and hormonal levels. Different types of mutations on chromosomal and gene level interrupt those pathways, which affect the further development of reproductive organs. Pathways are disrupted and couse variable developmental defects of both internal and external genital organs. The main goal of this work is to summarize these molecular processes that further affect the development of genitals in humans, possible developmental errors and their phenotypic subsequnet manifestations. Keywords: Reproductive organs, congenital anomalies, genetic disorders
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Molecular basis of human congenital anomalies
Kovačičová, Denisa ; Šípek, Antonín (advisor) ; Rothová, Olga (referee)
This bachelor thesis deals with the topic of congenital anomalies. The sorting of the congenital anomalies is discussed in the first two chapters. The third chapter concerns the mutations of the short arm of chromosome 17. I have chosen to describe the Smith - Magenis syndrome, which is caused by the deletion of 17p11.2, and the Potocki - Lupski syndrome, which is its reciprocal duplication. The gene RAI1 is specified in this part. The other topic mentioned in this thesis are RASopathies. The research of this section deals with the Noonan syndrome and focuses on mutations in genes PTPN11, SOS1, RAF1, KRAS and NRAS. In the fifth chapter the issue of thalidomide, its history and the mechanisms of action discovered up to now are described. The critical period and the mechanisms of limb reduction defects related to the timing of exposure are also defined here. New methods and findings related to these topics are discussed in the end of this work. Key words: congenital anomalies, teratology, ontogenesis, Potocki - Lupski syndrome, Smith - Magenis syndrome, RASopathies, Noonan syndrome, thalidomide
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Nursing Care of Children with Orofacial Clefts
Svobodová, Hana ; Hošťálková, Monika (advisor) ; Babická, Marcela (referee)
In the theoretical part I deal with cleft lip and palate, their distribution, risk factors, prevention, diagnosis and tretment. It also the nursing care of children with cleft lip/palate the infant and toddler period. The main objective of the thesis is to determine what is the nursing care for children with orofacial cleft. In addition, three sub-objectives have been established. The first goal was to find out what the nursing care is in the field of nutrition in children with cleft face. The second goal was to survey, what the nursing care of is wound in children after orofacial surgery. The last goal was to learn about the parents' awareness of the care with facial cleft. All objectives have been met. For the qualitative research as a method for data collection, was used nursing care report. The default method for the assembly of two case reports, was conducted and interview with mothers of children according to the structure of the model by M. Gordon - Model functional health patterns. Furthermore, the method of observation was used to compile the said case reports, and so was used medical documentation. Key words: orofacial cleft, children, nursing care, prevention, congenital anomalies
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